The Isthmus of Suez in Egypt is the narrow land connection between Africa and Asia—not between Asia and Europe. It separates the Mediterranean Sea from the Red Sea. The Suez Canal (completed 1869) cuts through this isthmus, creating a vital shipping shortcut between Europe and Asia without circumnavigating Africa.
Europe and Asia are part of the same continental landmass (Eurasia); their boundary is conventionally drawn along the Ural Mountains, Ural River, Caspian Sea, Caucasus Mountains, and Turkish Straits—not an isthmus.