The Karakum Desert lies entirely in Central Asia, between the Caspian lowland (west) and the Amu Darya River Valley (east/south). It is the world's seventh-largest desert, covering ~350,000 km² (140,000 sq mi).
Karakum is closely related to the Kyzylkum and Taklamakan deserts. They share:
These deserts form a contiguous arid zone across the heart of Asia.