- Shubenacadie River: This river is the longest in Nova Scotia, flowing for approximately 150 kilometers. It originates in the Cobequid Mountains and drains into the Minas Basin.
- Annapolis River: The Annapolis River is located in the Annapolis Valley and is approximately 125 kilometers long. It flows from the Annapolis Highlands and drains into the Bay of Fundy.
- St. Mary's River: The St. Mary's River is located in southwestern Nova Scotia and is approximately 115 kilometers long. It flows from the Tobeatic Wilderness Area and drains into the Bay of Fundy.
- LaHave River: The LaHave River is located on the South Shore of Nova Scotia and is approximately 105 kilometers long. It originates in the Blue Mountains and drains into the Atlantic Ocean.
- Margaree River: The Margaree River is located on the western coast of Cape Breton Island and is approximately 100 kilometers long. It originates in the Cape Breton Highlands and drains into the Gulf of St. Lawrence.
- Medway River: The Medway River is located in southwestern Nova Scotia and is approximately 95 kilometers long. It originates in the South Mountain and drains into the Atlantic Ocean.
- Tusket River: The Tusket River is located in southwestern Nova Scotia and is approximately 90 kilometers long. It originates in the South Mountain and drains into the Atlantic Ocean.