Admission of Texas, a vast territory south of the Missouri Compromise line, would upset the political balance, giving Southern slaveholders disproportionate influence in the Senate and Electoral College.
Many Northerners opposed territorial expansion that extended slavery. Texas annexation seen as gateway to further Southwest acquisitions, perpetuating slavery.
Mexico did not recognize Texas independence; annexation viewed as aggression. Northerners feared war with Mexico and further territorial disputes.
Some Northerners believed new agricultural territories would increase competition from Southern cotton and wheat, depressing Northern industries.
Annexation seen as a Southern move to enlarge political power. Resistance to expansion catering primarily to Southern demands, challenging regional equilibrium.