1. The Inca Empire: The Inca Empire was a powerful and well-organized state at the time of Pizarro's arrival. It had a large army, a strong economy, and an extensive network of roads and communication. Pizarro and his men were greatly outnumbered and outmatched in terms of military strength.
2. The Terrain: The terrain of Peru was also a significant challenge. The Andes Mountains, with their high altitudes and difficult passes, made it difficult for Pizarro and his army to move quickly and easily. They also had to contend with dense jungles and rivers that were difficult to cross.
3. Disease: Disease was another major problem that Pizarro and his men faced. Smallpox, measles, and other European diseases had not previously existed in the Americas and were devastating to the indigenous population. This resulted in a significant loss of life and weakened the Inca Empire's ability to resist the Spanish invasion.
4. Logistics: The logistics of supplying and maintaining an army in such a remote and hostile environment were also a major challenge. Pizarro had to ensure that his men had adequate food, water, weapons, and ammunition. This required a complex and efficient supply chain, which was difficult to establish and maintain in the conditions that Pizarro faced.