- Lake Superior, Lake Michigan, Lake Huron, Lake Erie, and Lake Ontario
Mississippi River
- Longest river in North America: flows through 10 states,
Ohio River
- Major tributary of the Mississippi River
Great Plains
- Vast grasslands covering central and western Midwest
Central Lowlands
- Region of rolling hills and plains covering much of Midwest
Ozarks
- Uplands region covering parts of Missouri, Arkansas, and Oklahoma
Black Hills
- Mountain range in western South Dakota and northeastern Wyoming
Driftless Area
- Region in southwest Wisconsin, southeast Minnesota, northeast Iowa, and northwest Illinois that was not covered by glaciers during last ice age.