Missouri straddles regional boundaries—geographically Midwestern, culturally split between Midwest and South.
Midwest: US Census Bureau places Missouri in the Midwest Region (East North Central division). Physiographically: Northern Plains (north of Missouri River), Ozark Plateau (south).
Little Dixie (Central MO, MO River): Hemp/tobacco plantations, enslaved labor, Southern culture. Counties: Boone, Howard, Cooper, Saline, etc.
Bootheel (Southeast): Mississippi Delta extension. Cotton, sharecropping, Deep South culture.
St. Louis/Kansas City Metros: Northern/immigrant/industrial — Midwest identity.
Ozarks (South): Upland South culture — similar to Arkansas/North Texas.
Missouri Compromise (1820): Admitted as slave state (balanced by Maine free).
Civil War: Border state — two governments, guerrilla warfare, 110,000 Union / 40,000 Confederate troops from MO.
Migration: Post-war: Southerners south, Northerners north/urban.
Politics: Rural = Southern conservative. Urban = Midwest moderate/liberal. Bellwether status lost (2008, 2012 voted opposite winner).
Speech: North = Inland Northern. South = South Midland. "Missour-uh" vs. "Missour-ee."
Food: St. Louis pizza (Provel), Kansas City BBQ (burnt ends) vs. fried catfish, cornbread, greens (South).
Missouri embodies the Midwest-South transition zone—geographically central, culturally contested.