The Protestant Reformation (1517 onward) and ensuing Catholic–Protestant wars profoundly influenced who settled the Americas, where, and why.
Monarchs mandated conversion of Indigenous peoples. Jesuit, Franciscan, Dominican missions spread Catholicism from California to Chile. The Spanish Inquisition extended to colonies; Sephardic Jews fled to New Amsterdam (NYC) and Caribbean.
Persecution of Puritans (wanted to "purify" the Church of England) and Separatists/Pilgrims (wanted total separation) drove the Great Migration (1620–1640): Plymouth, Massachusetts Bay, Connecticut, New Haven.
Quakers (Society of Friends) faced imprisonment in England; William Penn founded Pennsylvania (1681) as a "Holy Experiment" in religious liberty.
After the Revocation of the Edict of Nantes (1685), ~200,000 Huguenots fled—many to South Carolina, New York, Virginia, Caribbean.
Religious diversity became a defining feature of British North America, culminating in the First Amendment (1791): "Congress shall make no law respecting an establishment of religion…"