Did France Give Most of Louisiana to Spain?

No. France did not give "most of Louisiana" to Spain in a single transfer. Instead, through a series of treaties (notably the 1762 Treaty of Fontainebleau and the 1763 Treaty of Paris), France ceded the territory of Louisiana west of the Mississippi River (including New Orleans) to Spain, while the territory east of the Mississippi went to Britain. Later, Spain returned Louisiana to France (1800), who then sold it to the U.S. in the 1803 Louisiana Purchase.