- Coco River (Río Coco): It forms part of the border with Honduras and is the longest river in Nicaragua.
- San Juan River (Río San Juan): It forms the border with Costa Rica and drains Lake Nicaragua into the Caribbean Sea.
- Grande de Matagalpa River (Río Grande de Matagalpa): It flows through the Matagalpa Department.
- Prinzapolka River (Río Prinzapolka): It flows through the North Caribbean Coast Autonomous Region.
- Wawa River (Río Wawa): It flows through the North Caribbean Coast Autonomous Region and is a major source of hydroelectric power.
- Escondido River (Río Escondido): It flows through the South Caribbean Coast Autonomous Region.
- Tuma River (Río Tuma): It flows through the Matagalpa and Boaco departments and is a major source of hydroelectric power.
- Chiquito River (Río Chiquito): It flows through the Matagalpa and Boaco departments.
- Tipitapa River (Río Tipitapa): It flows from Lake Managua to Lake Nicaragua.