Athletes:
- LeBron James, basketball player, born in Akron
- Jesse Owens, track and field athlete, world record holder in multiple events, born in Oakville
- Jim Brown, football player, born in St. Simons, Georgia, but attended school and began his career in Ohio
- Archie Griffin, football player, first NCAA Division I FBS player to win two Heisman Trophies, born in Columbus
Actors:
- Halle Berry, Academy Award-winning actress, born in Cleveland
- Paul Newman, Academy Award-winning actor, grew up in Shaker Heights
- Steve Carell, actor and comedian, grew up in Concord
- Katie Holmes, actress, born in Toledo
Musicians:
- Dean Martin, singer and actor, born in Steubenville
- Michael Jackson, King of Pop, born in Gary, Indiana, began his musical career in Ohio with the Jackson 5
- Chrissie Hynde, lead singer of The Pretenders, born in Akron
- Machine Gun Kelly (MGK), musician and rapper, born in Houston, Texas, grew up in Cleveland
Inventors and Engineers:
- Thomas Edison, inventor and "Father of the Light Bulb," established labs and worked on several inventions while residing in Ohio
- John Glenn, astronaut and U.S. Senator, born in Cambridge
- Garrett Morgan, inventor of the gas mask and three-position traffic signal, lived and worked in Ohio
Writers:
- Toni Morrison, Nobel Prize-winning author, born in Lorain
- J.D. Vance, author of "Hillbilly Elegy," grew up in Middletown, Ohio
- Sherwood Anderson, author and member of the American literary movement, lived and worked in Ohio
- Neil DeGrasse Tyson, astrophysicist, author, and science communicator
This list is non-exhaustive, and many other notable and famous people are linked to Ohio throughout history.