Take a tour. There are several that have prime spots chosen for specific tours. Check with tour operators in the Hollywood area.
Get closer. If you want a photo of yourself in front of the sign, you need to take Canyon Drive or Bronson Avenue all the way up to the sign.
Go shopping. The mall at Hollywood and Highland affords a good view of the Hollywood sign. Bring a camera with a good zoom lens and try different angles.
Take a photo from Bronson Avenue or Gower Avenue just off Hollywood Boulevard. Watch out for traffic if you step off the sidewalk to get a good shot.
Hike up to the Hollywood sign. If you have the stamina, a good map and a good sense of direction, it is definitely worth the effort.