Iroquois Confederacy: The Iroquois Confederacy, also known as the Haudenosaunee, is a league of six Native American nations: the Mohawk, Oneida, Onondaga, Cayuga, Seneca, and Tuscarora. The Iroquois originally inhabited the Northeastern Woodlands, including parts of present-day New York, Pennsylvania, and Ohio. While they were not primarily located in the Appalachian Mountains, they had some presence and influence in the region.
Catawba: The Catawba are a Siouan-speaking people who originally lived in the Piedmont region of present-day North and South Carolina. They had some presence in the Appalachian Mountains, particularly in the areas near the Catawba River.
Shawnee: The Shawnee are an Algonquian-speaking people who originally lived in the Ohio River Valley and surrounding regions. They had some presence in the Appalachian Mountains, particularly in the areas of present-day West Virginia and Kentucky.
Delaware: The Delaware, also known as the Lenape, are an Algonquian-speaking people who originally lived in the Mid-Atlantic region of present-day New York, Pennsylvania, New Jersey, and Delaware. They had some presence in the Appalachian Mountains, particularly in the areas near the Delaware River.
These are some of the main Native American tribes that historically lived in or had connections to the Appalachian Mountains.