* Location: Bolivia, Chile, Peru
* Population: Approximately 2 million
* Language: Aymara
* Religion: Roman Catholicism, traditional Andean beliefs
* Culture: The Aymara are a traditionally agricultural people who live in the high Andes mountains. They are known for their elaborate textiles and their music.
* History: The Aymara were one of the most powerful civilizations in the Andes before the arrival of the Spanish. They were conquered by the Spanish in the 16th century and have been marginalized ever since.
Quechua
* Location: Peru, Bolivia, Ecuador, Chile, Argentina, Colombia
* Population: Approximately 10 million
* Language: Quechua
* Religion: Roman Catholicism, traditional Andean beliefs
* Culture: The Quechua are a diverse people who live in a variety of environments, from the Andes mountains to the Amazon rainforest. They are known for their textiles, their music, and their literature.
* History: The Quechua were the dominant civilization in the Andes before the arrival of the Spanish. They were conquered by the Spanish in the 16th century and have been marginalized ever since.
Mapuche
* Location: Chile, Argentina
* Population: Approximately 1.5 million
* Language: Mapudungun
* Religion: Roman Catholicism, traditional Mapuche beliefs
* Culture: The Mapuche are a traditionally agricultural people who live in the forests of southern Chile and Argentina. They are known for their textiles, their music, and their warrior culture.
* History: The Mapuche were never conquered by the Spanish and they have maintained their independence to this day.
Guarani
* Location: Paraguay, Brazil, Argentina, Bolivia
* Population: Approximately 10 million
* Language: Guarani
* Religion: Roman Catholicism, traditional Guarani beliefs
* Culture: The Guarani are a traditionally agricultural people who live in the rainforests of South America. They are known for their textiles, their music, and their food.
* History: The Guarani were one of the first peoples to be encountered by the Spanish in the Americas. They were decimated by disease and warfare, but they have survived and their culture continues to thrive.