The drive from Honolulu (Oʻahu) to Kamuela (Waimea, on Hawaiʻi Island) isn't a simple road trip—it requires an inter-island flight or ferry plus a drive. But if you're asking about the air distance (great-circle), it's approximately 103.5 miles (166.6 km). By car on Hawaiʻi Island, the journey from Hilo or Kona airports to Kamuela takes 1.5–2.5 hours through stunning volcanic landscapes. There is no direct road between the islands.