The premise of driving from South Carolina to California requires correction: while physically possible via Interstate highways, the distance (~2,300–2,500 miles depending on route) makes flying the only practical option for most travelers.
Distance: ~2,400 miles via I-20/I-10 or I-40. Time: 35–40 hours pure driving (4–5 days with rest). Cost: $350–$500 fuel + $400–$800 lodging/meals = $750–$1,300+ solo. Only economical with 3+ people sharing costs.
Amtrak: Silver Service/Palmetto to Crescent to Southwest Chief or Auto Train + connections. 60–72 hours. $300–$800+. Scenic but slow.
For 95%+ of travelers: Fly. Book 3–6 weeks ahead for best fares. Use Google Flights, Skyscanner, or airline sites. Consider nearby airports (e.g., SNA instead of LAX, OAK instead of SFO) for savings.
The cross-country drive remains an American rite of passage—but as adventure, not transportation.