Distance from Medford, OR to San Francisco, CA

Medford, Oregon to San Francisco: Straight‑Line vs. Driving Distance

Straight‑line (air) distance: ~325 miles (523 km)
Driving distance: ~335‑350 miles (540‑560 km) via I‑5 South
Driving time: ~5.5‑6 hours (normal traffic)

The route follows I‑5 through the Siskiyou Mountains (Stewart Summit, 4,310 ft), then the Central Valley. Winter weather at the pass can cause delays; carry chains Nov‑Apr.