Treaty of Paris (1783) — Ended Revolutionary War. Ceded 13 colonies + territory to Mississippi River. (Florida returned to Spain separately.)
Louisiana Purchase (1803) — $15M. 828,000 mi² (Mississippi River to Rockies, Gulf to Canada). Doubled US.
Adams-Onís Treaty (1819) — Ceded East & West Florida. Defined US boundary to Pacific (ceded Oregon Country claims).
Treaty of Guadalupe Hidalgo (1848) — Ended Mexican War. $15M + assumed claims. Ceded CA, NV, UT, AZ, NM, CO, WY (Mexican Cession).
Gadsden Purchase (1853) — $10M. Southern AZ/NM strip for railroad.
The four above (Britain, France, Spain, Mexico) transferred the vast majority of the contiguous 48 states.