Faster Route: Chicago to Nashville via I-57 or I-65?

I-57 South → I-24 East (Route 57) is faster:

• Distance: 486 mi
• Time: 7 hr 51 min
• Pros: Shorter, more direct, less congestion.
• Cons: More tolls (Illinois), fewer services, curvier.

I-65 South (Route 65) is slightly longer:

• Distance: 510 mi
• Time: 8 hr 2 min
• Pros: Fewer tolls, more rest stops, straighter.
• Cons: Longer, heavier traffic (Indianapolis, Louisville).

Bottom line: I-57/I-24 saves ~11 minutes and 24 miles; choose I-65 if you prefer more amenities.