The driving distance between Louisville, Kentucky and Mount Rushmore National Memorial in South Dakota is approximately 1,085 miles (1,746 kilometers) via the most direct interstate route.
Primary Route: I-64 W → I-70 W → I-76 W → I-80 W → I-25 N → US-16 W / US-385 N → SD-244
Major Cities En Route: St. Louis, Kansas City, Topeka, Denver, Cheyenne, Casper, Rapid City
Driving Time: ~16-17 hours non-stop; realistically 2-2.5 days with rest
Fly Louisville (SDF) → Rapid City (RAP) via Chicago (ORD), Denver (DEN), or Dallas (DFW): ~4-6 hours total. Rent car for 45-minute drive to Mount Rushmore.