Distance from Orlando to the Florida Keys

~235 miles (378 km) from Orlando to Key Largo (northernmost Key).

• Drive: ~4–4.5 hours via Florida's Turnpike → US-1 (Overseas Highway).
• Fly: Orlando (MCO) → Key West (EYW) ~1 hour (daily flights on American, Delta, United).

Key West is another ~100 miles (1.5–2 hrs) down US-1 from Key Largo.