Driving Time: Las Vegas to the Florida Keys

~2,500 miles (4,000 km) from Las Vegas to Key West.

Non-stop driving: 38–42 hours (pure driving, no sleep). Realistically: 4–5 days with rest, fuel, food, overnight stops.

Route: I-15 S → I-40 E → I-75 S (or I-10 E → I-75 S). Major cities: Flagstaff, Albuquerque, Amarillo, Oklahoma City, Dallas, Houston, San Antonio, then across Gulf Coast to Florida.

Flying (LAS → EYW/MCO + drive) is far more practical: ~5–6 hours total.