Try to schedule flights with the shortest routes possible. Direct flights are the best option. The less time your pet is in the air and moving around, the less panicked she'll feel.
Put your pet in his carrier and let him get used to being inside it for extended periods. Before putting your pet on a plane, try taking some shorter trips in the car with your pet in his carrier. This will allow your pet to adjust to being in the carrier while going to different places.
Bring some of your pet's favorite toys and treats along on the plane. These items may distract your pet by keeping her occupied.
Bring your pet some food and water if your flight is expected to last more than three hours.
Allow your pet to go to the bathroom just before the plane ride, during any extended layovers and immediately after arrival at your final destination. Some pets may feel increased anxiety when they find they need to go during the plane ride.
Consult with your veterinarian if your pet is known to anxiety on plane trips. Depending on your animal's overall health and condition, the veterinarian may prescribe mild sedatives or other medications to help lower your pet's anxiety levels.