Your point of origination should be your point of return on a round trip flight. Some affordable airlines book travel in one way segments allowing you to fly into one airport and out of another airport.
Shop around to find the best prices. Flying round trip costs you less. Consider nearby destinations, as a round trip ticket to and from your closest airport may not give you the best price. Many cities have more than one airport to choose from.
You have limited options if you face uncertain return dates for your air travel. Open-ended tickets, with no predetermined return date, are most convenient. For open ended travel, purchase two one-way flights.