The Cheyenne River is a significant tributary of the Missouri River, draining a vast area of the northern Great Plains.
It originates in the Black Hills of northeastern Wyoming (near the Thunder Basin National Grassland), flows northeast across the high plains, and enters South Dakota. After passing through the Cheyenne River Indian Reservation and skirting the Badlands, it joins the Missouri River at Lake Oahe near Pierre, South Dakota. Total length: approximately 450 miles (720 km).
The river's name comes from the Cheyenne people (Dakota: Šahíyena), who historically inhabited the region.