Although they look a little goofy, neck pillows like the ones you see for sale in most airport shops can be a lifesaver while you make a journey on a Greyhound bus. If it will allow you to sleep more comfortably aboard a plane during a four or five hour flight across the country, then imagine how much it will help pass the time while you are riding in a bus seat for a 20-hour or longer trek across the states.
Pack one of these inflatable devices in a carry-on bag and blow it up when you feel like getting some rest. Save it for the legs of the trip that are extended so you do not need to transfer right in the middle of a nap.
Remember that hopping a bus also became more secure after September 11, 2001. The airline industry was not the only one to make changes following the tragedy. Greyhound wants to verify whom they are allowing on board as well. Do not forget to have your photo ID on hand when you get on the bus, and don't forget to keep it with you throughout the trip. You'll likely have to show it each time you change buses.
Buses can be cramped and somewhat uncomfortable. The days of traveling in your Sunday best are long gone. Dress for comfort and go casual. Depending on the weather, opt for a T-shirt and shorts or your favorite comfy jeans and a sweatshirt. If you are going to be on the Greyhound overnight, think about what you'll be comfortable sleeping in. You won't have the opportunity to change clothes en route.
One advantage riding the Greyhound has over flying to your destination is a more relaxed attitude toward carry-on items. You can bring along water and snacks without a problem, and you won't have to go past a security checkpoint before you can purchase them. Having a couple of bottles of water and a good traveling snack like trail mix or an apple can make the wait for the next available restaurant much more tolerable.
If there are crowded buses headed in your direction, Greyhound may be running multiple buses on the same route. It may be a while before you can hop the next one, but your ticket may be honored for any bus going the same way. Ask a representative at the station if there will be a second bus. If so, it is very likely that the second one will be less crowded. You may even get a row to yourself, which makes the trip much better.