Visit Greyhound's website to purchase tickets and look at routes. Certain routes do allow reservations, and for $5 extra you can board first. Track where the bus departs and arrives to prepare for a safe arrival.
Pack lightly in order to be able to move more conveniently. Baggage assistance is available for elderly riders and those with disabilities. One bag per customer is checked for free and the second costs $10, as of 2011. Bring entertainment necessities like an iPod or portable music player. Also bring a blanket and a small pillow if traveling overnight.
Get a good seat on the bus by coming early. If the bus is pretty full, it is important to grab a window seat. One of the best parts of bus travel is being able to watch the scenery through their wide panoramic windows while not having to focus on driving.
Bring money or bring snacks with you. The bus makes frequent stops, so there are ample places to get food along the way. If you are a picky eater, then you may want to bring your own food.