Plan a budget. This will give you an idea of what type of bus tickets you can afford and which companies you can use. Fully refundable tickets cost more, but allow you to get a full refund if you change your plans. Many bus companies offer web-only fares that offer cheaper tickets online. If you have enough money in your budget for a hotel room, you can take some time away from bus travel and do some sightseeing. Greyhound, for example, offers a discovery pass that allows you stopover options.
Purchase a specific reserved seat, if possible. This will make the journey more enjoyable and comfortable. If you plan on bringing a laptop or other electronic device, buy a ticket for a seat next to an outlet. They are typically placed at the front or rear of the bus. Some rows, such as those along emergency exits or by stairs, usually have more leg room than others. To keep your trip odor free, book a seat far away from the restroom. If you are traveling with a laptop and wish to stay away from odors, then the front of the bus is the best option.
Determine your route, including some sightseeing stops that you may want to make along the way. Book your hotels in advance to save money, as long as the stops do fit your budget.
Bring food and snacks. Most buses, if they stop at all, will stop over at roadside cafes and diners, where meal selection may be limited. Take foods that travel easily such as fruit and sandwiches. Bring bottled water to quench your thirst. Peanut butter and jelly, as well as dry snacks such as crackers, travel better than meat or tuna sandwiches.
Bring a distraction -- such as a laptop, DVD player or MP3 player -- to help pass the time. Here's where having an outlet seat will come in handy. You'll even find wireless Internet connections on some buses, so you can keep in touch while you're out on the road.