Wash your trailer often, especially after each trip. Use a mild detergent and a sponge or soft brush. Most newer travel trailers have a rubberized roof which should be cleaned at least four times per year. Roof manufacturers and RV supply stores offer special cleaning products for rubber roofs, but you can also use a mild laundry detergent. While cleaning it, inspect the roof for cracks or tears caused by low-hanging branches. Check for leaks around roof vents, air conditioner covers, and TV antennas.
Check the condition of your battery at least once per month. If it is not a sealed maintenance-free battery, remove the caps covering the cells and check the water level. Add distilled water if necessary. A battery tester can directly read the condition of the battery's electrolyte. Test a sealed battery with a voltmeter to ensure that it produces 12 volts when fully charged. Cracks or bulges in the battery case indicate that it is time to replace it. Check the battery cables and clean any corrosion. If the trailer will be stored for a long time, disconnect the battery cables to prevent battery drain.
Drain your black and gray water waste tanks after each trip. After draining, pour in several gallons of water and a pound of baking soda into each tank. Tow the trailer for a few miles to break up any deposits, then completely drain the tanks. When using the trailer at a campground with waste water hookups, do not leave the drains open. Allow the tanks to get about half full before opening the valves to drain them. This will help flush them out more effectively.
Drain the fresh water tank at least once per month. Every six months (or more often if you use the trailer in very warm climates), "shock" the tank with a strong chlorine bleach solution. Drain the hot water heater every six months. Check the condition of the electrode (if it is an electric heater) and replace if it is corroded.
Check the condition and pressure of your tires at least once per month, and before each trip. Use a torque wrench to check that all wheel lug nuts are tightened to the manufacturer's specifications. If you leave the trailer in a sunny location for extended periods of time, use tire covers to protect the tires from the effects of the sun. Check wheel bearings and have a professional lubricate them once per year.