Find out the exact weight of the towed vehicle. The manual to the motor home will give you a precise idea of how much the motor home can handle. Factor in the added weight of supplies, passengers, and accessories. Also, each hitch will have a different weight rating, so always buy the hitch with a firm idea of what requirements you have for it.
Distribute the weight properly and set the tire pressure to the correct measurements. In order to distribute the weight for maximum effect, look up your tow vehicle's GAWR (gross axle weight ratings). With the GAWR and manual guides, you will be able to arrange the weight appropriately. Also, every motor home will have a different ideal tire pressure, which helps it better handle the weight. The center of gravity should always be kept relatively low.
Consider installing a separate breaking system if your load is over 1200 pounds. You should also research the law in your given states, since some have legal stipulations on towing vehicles of a certain weight. All states require the towed vehicle to have operating taillights. Make sure your mirrors give you visibility around on the sides and behind your vehicle.
When you hit the road, keep an eye out for the swaying of your towed vehicle. If it is swaying, that is probably because of poor weight distribution. Keep in mind that stopping quickly will cause your towed vehicle to sway, too. While the towed vehicle is in motion, no passengers should be in it.