The safety of Class C motor homes is generally considered better than that of Class A models and other motor homes in general, as Class C motor homes were adapted from standard road vehicles and therefore have all the natural safety amenities of standard road vehicles. Most specifically, the cockpit construction has a frontal crush area and all-steel cage, offering protection for driver and passenger in a rollover situation---protection that is either minimal or completely lacking in a Class A. These models also have better handling on the road, making them generally safer in inclement weather, sharp curves and uneven surfaces.
Inside the Class C motor homes, the over-cab area can be used for a bed or, as seems to be more popular in newer models, a mounted television and entertainment center. This gives a real sense of space and roominess to the interior of the Class C motor home itself, as this could never be done in a Class A motor home, as the driving area makes up the front of the bus, making it impossible to mount anything. However, this is only a good idea in newer models of Class C motor homes. TVs mounted to the wall in the over-cab area have been known to fall and cause injury to people watching below and in the driver's cab itself. Regardless of what model you have, if you're going to mount a TV in your Class C motor home, make sure it is attached securely, as the walls of this home often shake when the vehicle is moving.
The chassis on Class C motor homes is really what makes them stand apart from other motor homes, as it is cutaway after the truck cab, with the rest of the motor home's amenities placed on top of it. This allows manufacturers to add multiple slideouts without overloading and to design a variety of styles and floorplans so that each Class C motor home feels like a unique home of its own. However, it should be noted that too many slideouts can weaken the structural integrity of the vehicle in general and should be purchased with caution.