Book your ticket by calling Rail Europe at (888) 382-RAIL or visiting their Web site (see Resources).
Use your Eurail or Rail Europe pass for all travel after Munich to Italy to save some money.
Reserve your trip to Munich as far in advance as possible, especially if you want a sleeper car or first-class seat, as this is a heavily traveled business corridor.
Be aware that some Munich-bound evening trains departing from the Czech Republic are sleeper-car-only accommodations with fares to match, so book accordingly!
Know that all passengers en route to Italy from the Czech Republic must transfer in Munich, Germany.
Familiarize yourself with the 24-hour military time clock in order to avoid confusion when trying to read European train timetables.
Choose travel from the Czech Republic into major Italian cities Milan, Venice, Turin and Rome via Munich, and add a leg from there to other points in Italy.
Stop over in Munich for a day or two to stretch your legs en route to Italy, and add another city to your travelogue.
Be sure to check your Munich connection when confirming travel to Italy from the Czech Republic.
Board with travel documents in hand and keep them close at all times. You may be asked to produce them repeatedly along the way.