Book your tickets online at Rail Europe's Web site (see Resources) or call (888) 382-RAIL.
Opt for first class and get a meal and beverages free of charge.
Purchase your tickets no less than a day or two in advance. The trains to Switzerland rarely leave the Czech Republic at less than full capacity, regardless of whether they leave in the morning, afternoon or evening.
Sleep soundly on a "red eye" train into Zurich from the Czech Republic by booking a sleeper car on the late train.
Choose an evening train into Zurich to spare a regional stop or two, ultimately reducing your travel time by about an hour.
Take the Metro Line C subway to either of Prague's large train stations to save yourself the headache of haggling with cab drivers.
Make reservations as far in advance as possible, given the popular nature of train travel between the Czech Republic and other European countries, such as Switzerland.
Spring for first-class leg room and comfort, as it will take approximately 13 hours from either Prague train station to the one in Zurich, Switzerland. You may want to stretch out or nap.