Enter the I-75 South from Atlanta. Continue traveling south for about 70 miles.
Take exit 177 to I-475. The I-75 splits into I-16 and I-475 just before Bolingbroke, and taking I-475 keeps you traveling south and serves as a detour around traffic in Macon. Merge back onto I-75 from the exit on the left after about 15 miles and continue southbound for another 57 miles.
Exit I-75 at exit 300, which leads to the GA-300 South. After 35 miles, merge right onto Clark Avenue, then follow the loop to merge back onto the US-19 South/GA-300 South/Liberty Expressway. Travel southeast on this highway for another 52 miles.
Make a right on County Line Road, also called GA-202. Travel on this road for about 2 miles.
Make a right at US-319 South, the Wiregrass Georgia Parkway. Follow US-319 South to the left as it becomes West Thomasville Bypass. This highway loops around the entire city. To go to the center of town, make a left where the US-319 south becomes West Jackson Street, after about 4 miles.
Turn right on Broad Street to end the trip in downtown Thomasville.