Follow the path of Ancient Rome's most epic places: the Colosseum, the stage for gladiator battles; the Arch of Constantine; Circus Maximus, home of the chariot races; and Palazzo Venetia, where you'll find many of the city's first Renaissance buildings.
While in Rome, explore the glorious Vatican City, including the Sistine Chapel, which is home to one of Michelangelo's greatest masterpieces.
Besides taking advantage of the fantastic food and wine, make time to visit Mt. Vesuvius in Naples, at the foot of which rests the ruins of the village of Pompeii.
See the famous Leaning Tower of Pisa in Tuscany. It's a beautiful work of architecture that stands 8 stories tall, standing at a tilt toward the southeast because of a poorly laid foundation in 1173.
Explore the magical canals of Venice by gondola. Be sure to stop at the Grand Canal, the main center that's full of Renaissance palaces, theatre venues and Gothic buildings.