Fast food is available almost everywhere, so pack some healthier, non-refrigerated snack options as an alternative to greasy burgers and fries. Granola and granola bars or trail mix offer fiber and will help keep the travelers full. Air-popped popcorn or apples with peanut butter are low-calorie options. Include some whole wheat crackers to help curb any nauseous stomachs along the way. For those with a sweet tooth, pack some cookies that offer some nutrients, such as oatmeal raisin. Don't forget to include a few bottles of waters, napkins and moist towelettes.
Create a custom CD with a collection of songs tailored to the person receiving the care package. Include some new music that the recipient of your gift may not have heard for some variety.
Books on tape are another option for the literature enthusiast. Pack some coloring or activity books, sketchpads, markers and crayons to keep little ones occupied.
Include a few sets of ear plugs for those in the car who want some peace and
quiet.
Purchase some basic medical supplies and safety items for your care package. Band aids, antiseptic cream, and over the counter medication for indigestion, nausea and pain relief can help with minor medical problems that may arise while on a road trip. A small flashlight and a can of instant tire-inflator will come in handy if a flat tire occurs. Consider including a small notebook and pen, duct tape and extra batteries.
If you are familiar with the area to which the travelers are going, create a list of places to stop along their route. Mark different restaurants, photo opportunities, hotels, recreational parks, tourist attractions or other places of interest on a map. This will take some of the planning pressure off the travelers and give them the opportunity to try out new places. Include phone numbers of these places if you can in case the travelers need to call for information or directions.
While gift cards may not seem like a very glamorous gift, they are often very practical for travelers. Gas cards help defray the cost of fuel. A gift card for a hotel stay is valuable for those on long journeys. Think about a gift card to a restaurant or spa for when the travelers arrive at their destination. Not many things beat a good meal or massage after a long trip in the car.