Consider the overall capacity and bulk of the pack. A roomy travel pack should expand to hold between 3,000 and 6,000 cubic inches, and the frame should be lightweight.
Look for lots of inside and outside pockets that will allow a variety of items to be stowed in the pack with maximum accessibility.
If you are a woman, or buying a pack for a woman, look for a travel pack especially proportioned to fit women, who generally have smaller bodies than men.
Make sure the pack has good suspension and load contour to help distribute the weight more evenly on the back and hips.
Look for convenient features such as a zip-off day pack, a real boon for travelers who wish to stow a large pack and use the smaller, lighter pack during the day.
Expect a good travel pack to cost between $150 and $300.