When traveling with a dog, you must decide whether to carry it with you in the cabin or transport it via the cargo hold. Cabin travel is usually the cheaper option, but the pet will count as your carry-on luggage and, of course, only pets small enough to fit inside a carrier that can be properly stored per the airline's guidelines are allowed. Fees may vary for these services: Alaska Airlines charges $100 each way for both cargo and cabin, while United charges $250 for a checked kennel versus $125 for cabin travel.
Some airlines require a health certificate from a veterinarian, issued within 30 days of the travel date. While Alaska Airlines requires a health certificate, as well as proof of rabies vaccine, for any pets crossing state lines, JetBlue has no current requirements for domestic travel.
Reservations must be made in advance for most airlines as they usually only allow a certain number of pets on each flight.
Sedatives are generally not considered a good idea as they can react in unpredictable ways at high altitudes, but your veterinarian is the best one to make recommendations for your dog.