Best way to drive from Destin Fl St. Louis Mo?

The best route to drive from Destin, Florida, to St. Louis, Missouri, is the following:

1. Start in Destin, Florida, and head north on US-331.

2. Continue on US-331 through Alabama, Georgia, and Tennessee, passing through cities such as Dothan, AL, Atlanta, GA, and Nashville, TN.

3. After Nashville, take I-24 West and continue through Kentucky and Illinois.

4. I-24 will take you to St. Louis, Missouri.

The total driving distance is approximately 850 miles, and the estimated drive time is around 14 hours and 30 minutes (without stops).

Note: The route and estimated drive time provided are approximate and may vary depending on road conditions, traffic, and weather. It's always a good idea to check the latest traffic updates and road conditions before embarking on a long road trip.