~150 miles (240 km) via I-4 West (most direct).
Drive time: 2 hours 20 minutes in normal traffic. I-4 through Orlando is a notorious bottleneck—add 30–60 min during peak hours/construction.
Alternative: FL-528 (Beachline) to Florida's Turnpike to I-75—similar distance, sometimes faster if I-4 congested.