Drive time: ~5 hours 15 minutes (320 miles / 515 km) under normal conditions.
Typical Route: I-10 West across the Panhandle—Pensacola → Mobile.
Mobile operates on Central Time (CT); Florida Panhandle west of Apalachicola River is also CT—no time change for most of the drive. East of that line (most of FL) is Eastern Time (ET).