* Mecca: The holiest city in Islam, Mecca is home to the Kaaba, a cube-shaped building that is considered the most sacred site in Islam.
* Medina: The second holiest city in Islam, Medina is home to the Prophet Muhammad's Mosque, which is considered the first mosque in Islam.
* Rome: The holiest city in Catholicism, Rome is home to the Vatican City, the smallest independent state in the world. The Vatican City is home to many important religious sites, including St. Peter's Basilica, the Sistine Chapel, and the Vatican Museums.
* Santiago de Compostela: A city in northwestern Spain, Santiago de Compostela is home to the tomb of Saint James the Great, one of the twelve apostles of Jesus.
* Varanasi: A city in northern India, Varanasi is considered the holiest city in Hinduism. It is located on the banks of the Ganges River, which is considered sacred by Hindus.
* Bodh Gaya: A city in northeastern India, Bodh Gaya is the place where the Buddha attained enlightenment. It is home to the Mahabodhi Temple, which is one of the most important Buddhist pilgrimage sites.
* Lhasa: The capital of Tibet, Lhasa is home to the Potala Palace, the former winter residence of the Dalai Lama. It is also home to many other important Buddhist temples and monasteries.
* Kailash Mansarovar: A mountain in Tibet, Kailash Mansarovar is considered sacred by Hindus, Buddhists, and Jains. It is located near the source of the four longest rivers in Asia: the Indus, the Ganges, the Brahmaputra, and the Sutlej.