Were Christian Crusaders Driven from Egypt in 1517?

No. The premise of the question contains a historical inaccuracy. The last major Crusader stronghold in the Levant, Acre, fell to the Mamluks in 1291, effectively ending the Crusader presence in the Holy Land—over two centuries before 1517.

Historical Context

• 1291: Fall of Acre; end of Crusader states in the Levant.
• 1517: Ottoman Sultan Selim I conquers the Mamluk Sultanate, bringing Egypt, Syria, and the Hejaz under Ottoman rule.

By 1517, there were no organized Christian Crusader forces in Egypt to be expelled. The Ottoman conquest was a conflict between Muslim powers (Ottomans vs. Mamluks), not a Crusader expulsion.