Driving Distance: Florence, KY to St. Louis, MO

The road distance from Florence, Kentucky (Cincinnati metro) to St. Louis, Missouri is approximately 330 miles (531 km).

Route & Time

• Primary: I-71 S → I-64 W (Louisville) → I-70 W / I-64 W → St. Louis.
• Time: ~5 hours (normal traffic).
• Key Choke Points: Louisville (I-64/I-71/I-65 Kennedy Interchange), St. Louis approach (Poplar St Bridge / Stan Musial Bridge).

Alternative

I-75 S → I-74 W → I-57 S → I-64 W (longer, ~360 mi, avoids Louisville but adds time). Not recommended unless major incident.