The fastest and most direct way to travel from Venice to Tuscany is by train. There are frequent trains from Venice Santa Lucia station to Florence Santa Maria Novella station, with a journey time of around 2 hours 30 minutes. From Florence, you can then take a regional train to other cities in Tuscany, such as Siena, Pisa, and Lucca.
By Bus
There are also several bus companies that operate direct services between Venice and Tuscany. The journey time by bus is usually a bit longer than by train, but it can be a cheaper option. Some of the main bus companies that operate this route include FlixBus, MarinoBus, and BusItalia.
By Car
If you are renting a car, you can drive from Venice to Tuscany in around 4 hours. The route is well-signposted and easy to follow. However, be aware that tolls apply on some sections of the motorway, and fuel costs can be high in Italy.
By Air
There are no direct flights from Venice to Tuscany. However, you can fly from Venice to Florence or Pisa with a stopover in Rome or Milan. The flight time is around 1 hour 30 minutes, and the total journey time including the stopover will be around 3-4 hours.