Frequent trains from Venice Santa Lucia to Florence Santa Maria Novella take ~2h 30m. From Florence, regional trains connect to Siena, Pisa, Lucca, and other Tuscan towns.
Companies like FlixBus, MarinoBus, and BusItalia offer direct services. Longer than train but often cheaper.
~4 hours drive via well-signposted motorways. Tolls and high fuel costs apply.
No direct flights. Connect via Rome or Milan to Florence or Pisa; total journey ~3–4 hours including layover.