1. Christopher Columbus: Christopher Columbus made four voyages across the Atlantic Ocean from Spain and reached the Caribbean in 1492. His voyages led to the European exploration and colonization of the Americas.
2. Juan Ponce de León: A Spanish explorer, Juan Ponce de León, set out from Puerto Rico in 1513 in search of the mythical "Fountain of Youth." Instead, he discovered Florida, which he named "La Florida."
3. Vasco Núñez de Balboa: A Spanish explorer and conquistador, Vasco Núñez de Balboa, set out on an expedition in 1513 and crossed the Isthmus of Panama. He became the first European to see the Pacific Ocean from the New World.
4. Hernán Cortés: A Spanish conquistador, Hernán Cortés, sailed to the Caribbean in 1519 and led an expedition to conquer the Aztec Empire. His victory over the Aztecs brought much of Mexico under Spanish control.
5. Sir Francis Drake: An English explorer and privateer, Sir Francis Drake, circumnavigated the globe between 1577 and 1580, including a voyage to the Caribbean Sea and raids on Spanish settlements in the region.
6. Henry Morgan: A Welsh privateer and buccaneer, Henry Morgan, operated in the Caribbean Sea during the 1660s and 1670s. He led numerous raids and attacks against Spanish settlements and ships in the region.
These are just a few of many explorers who made significant voyages to the Caribbean Sea during the Age of Exploration and the colonial era. Their expeditions contributed significantly to the knowledge of the region, the establishment of European colonies, and the shaping of its history.