Direction from Amarillo, TX to El Paso, TX: Southwesterly

Travel from Amarillo (Texas Panhandle) to El Paso (far west Texas) follows a southwesterly direction.

Primary route: I-40 West to I-25 South (via Tucumcari, Santa Rosa, NM) or continue on I-40 to Albuquerque then I-25 South. Total ~290 miles, ~4.5 hours driving.