Philadelphia – Southeastern PA, at the confluence of the Delaware and Schuylkill Rivers. ~130 mi NE of Washington, D.C.; ~90 mi SW of New York City.
Pittsburgh – Southwestern PA, where the Allegheny and Monongahela Rivers form the Ohio River. ~300 mi west of Philadelphia.
Both anchor major metro areas: Philadelphia (Delaware Valley, spanning PA/NJ/DE) and Pittsburgh (metro extending into WV/OH).