Control of the Mississippi was the linchpin of Union strategy—the "backbone of the rebellion" in Lincoln's words. Four intertwined imperatives drove the 1862–63 campaigns.
The river was the South's primary north–south artery. Supplies (Texas beef, Louisiana salt, Arkansas horses), troops, and cotton moved on steamers. Union control turned this highway into a barrier.
The Trans-Mississippi (Texas, Arkansas, Louisiana, Indian Territory) held vast resources and manpower. Isolating it prevented reinforcement of eastern armies and crippled the Confederate war economy.
Cotton—the South's financial lifeline—could not reach Gulf ports for blockade runners. Planters burned cotton; Confederate credit collapsed. The Union gained the same export route for Midwest grain.
Island No. 10 → Memphis → Vicksburg (Grant's masterpiece) → Port Hudson. By July 1863, "the Father of Waters flows unvexed to the sea." The war continued, but the South's capacity to win was broken.