How to Travel from Charlotte, NC to Charleston, SC

By Car (~4.5–5 hours, 200 miles)

1. Take I-85 South.
2. Exit 171B to merge onto I-26 East.
3. Continue 189 miles.
4. Exit 218 onto US-17 South (1.2 mi).
5. Right on Ashley River Road (1.5 mi).
6. Right on Meeting St → Downtown Charleston.

By Plane (~1 hour flight)

Direct flights: Charlotte Douglas (CLT) → Charleston International (CHS). Multiple daily.

By Bus

Greyhound runs Charlotte → Charleston; ~5–6 hours.

Best option: Driving for flexibility; flying for speed.